Hillaria®

The formation of tissue adhesions is a frequent consequence following surgical interventions. The adhesions occur as a result of adjacent internal organs coming into contact and forming fibrous tissue between them. Adhesion formation triggers a series of biological processes, including an acute inflammatory response due to damage to the peritoneal mesothelium. This inflammation encourages the growth of fibrous adhesions, which can cause various post-operative symptoms, such as chronic pelvic pain, bowel obstruction, restricted movement, dyspareunia, infertility, and a higher complication risk in subsequent operations. As a result, a second surgical procedure may be necessary to remove fibrous tissue. To ensure optimal surgical outcomes and prevent the development of post-surgical adhesions, it is advisable to employ Hillaria®. Hillaria® is a viscous gel with high transparency and biodegradability. This sterile gel is produced by crosslinking a unique type of Hyaluronic acid, which is a fundamental component of human connective tissue as well as epithelial and mesothelial tissue. Hillaria® has the capability of adhering to tissue surfaces and the abdominal wall, thereby creating a barrier that effectively prevents the formation of tissue adhesions. The indications of Hillaria® include its use in abdominal interventions, whether performed through laparotomy or laparoscopy, as well as in hysteroscopic procedures. Its primary purpose is to reduce the formation of adhesions subsequent to surgery. Each package of Hillaria® contains two sterile syringes of 5 ml (each mL provides 20 mg of cross-linked Hyaluronic Acid and 2 mg of Hyaluronic Acid), a leaflet and a set of tracking labels.

FAQ

What is Hillaria®?

Hillaria® is a bio-degradable, sterile, transparent, high viscous gel obtained by cross-linked hyaluronic acid which is used as an anti-adhesion barrier gel.

How is the mechanism of action of Hillaria®?

Hillaria® forms a physical barrier between damaged tissues, preventing them from adhering to each other during the critical wound healing period and also regulates cell signaling to effectively prevent post-surgical adhesions.

What are the ingredients of Hillaria®?

1 mL Hillaria® contains:

  • Cross-linked hyaluronic acid: 20.0 mg
  • Linear hyaluronic acid: 2.0 mg
  • Sodium chloride: 6.9 mg
  • Water for injection: 1.0 mL

What are the indications of Hillaria®?

Hillaria® is indicated for laparotomic or laparoscopic abdominal interventions and hysteroscopic interventions to reduce post-surgical adhesion formation.

How Hillaria® should be administered?

  1. After bringing the product to room temperature, open the pouch and transfer the syringe into the sterile field, adopting the normal aseptic techniques used in surgical theatres.
  2. Remove the protective cap on the tip of the syringe and insert the cannula/applicator.
  3. After aspiration of all irrigation fluid, apply the gel inside to completely cover all anatomical sites where adhesion prevention is desired; even if the thickness of the gel applied does not influence the efficacy of the product, it is recommended to apply a 1-2 mm thick layer of gel.
  4. Do not irrigate after application of the product.

What does the packaging of Hillaria® contain?

Each package contains one sterile 5 mL syringe of Hillaria®, a 23-centimeter cannula, a leaflet, and a set of tracking labels (one for patients and one for their records).

What are the advantages of Hillaria®?

Safety: Hillaria® is a biodegradable and bioabsorbable gel, and due to the natural nature of hyaluronic acid, its safety has been proven in many studies.

Effectiveness: The use of cross-linked hyaluronic acid gel in preventing adhesions following open and closed surgical interventions has been proven in many clinical studies.

Stability: Due to its high stability, cross-linked hyaluronic acid effectively prevents the formation of adhesions following surgery in the critical period of adhesion formation (5 to 7 days) and also prevents the formation of delayed adhesions.

Ease of Use: Hillaria® is in the form of a gel and is easily attached to tissue surfaces and the abdominal wall without the need for stitches, creating an anti-adhesion barrier.

How is the storage condition of Hillaria®?

  • Do not freeze or expose to extreme heat.
  • Store the product at a temperature between 2°C to 25°C.
  • Freezing of the product can result in severe bubbles formation. Do not use the product in this case, as the performance cannot be guaranteed.
  • The content is fragile.
  • Shelf life is 2 years, correctly preserved.

What is the important safety information about Hillaria®?

  • With regard to resections involving anastomosis sites, there is no clinical data available to prove the safety and performance of cross-linked hyaluronic acid.
  • Should not be used in patients with known hypersensitivity to hyaluronic acid and Gram-positive bacteria, as well as people with active infection or contamination of the surgical site.
  • This product is used only under surgical aseptic conditions by a licensed medical practitioner.
  • Once the package is opened discard any remaining gel after use.
  • Do not attempt to reposition gel once applied and do not apply additional layers of gel on top of one another.